As the United States commemorates its 250th anniversary, American cities are becoming increasingly important global centers for dynamic economic growth, successful civic innovation, strengthening community resilience, and engaging globally to attract talent and solutions. This bipartisan conversation with San Diego, California Mayor Todd Gloria and Columbia, South Carolina Mayor Daniel Rickenmann will examine how mayors are bringing together leaders from business, philanthropy, academia, and government to deliver results—from attracting foreign investment and expanding trade to revitalizing communities and advancing climate action. What can America’s cities teach us about the partnerships, leadership, and locally-driven solutions needed to strengthen the country’s global competitiveness and shape its role in the next century?